A novel Staphylococcus aureus vaccine: iron surface determinant B induces rapid antibody responses in rhesus macaques and specific increased survival in a murine S. aureus sepsis model.

@article{Kuklin2006ANS,
  title={A novel Staphylococcus aureus vaccine: iron surface determinant B induces rapid antibody responses in rhesus macaques and specific increased survival in a murine S. aureus sepsis model.},
  author={Nelly A. Kuklin and Desmond J Clark and Susan Secore and James T. E. Cook and Leslie D Cope and Tessie McNeely and Liliane Noble and Martha J Brown and Julie K Zorman and Xin Min Wang and Gregory D Pancari and Hongxia Fan and Kevin D Isett and Bruce Burgess and Janine Bryan and Michelle Brownlow and Hugh George and Maria S. Meinz and Mary E Liddell and Rosemarie Kelly and Loren G Schultz and Donna Montgomery and Janet C Onishi and Maria Losada and M{\'e}lissa Martin and Timothy Ebert and Charles Y. Tan and Timothy L. Schofield and Eszter Nagy and Andreas Meineke and Joseph G. Joyce and Myra B. Kurtz and Michael J. Caulfield and Kathrin Ute Jansen and William L McClements and Annaliesa S. Anderson},
  journal={Infection and immunity},
  year={2006},
  volume={74 4},
  pages={2215-23}
}
Staphylococcus aureus is a major cause of nosocomial infections worldwide, and the rate of resistance to clinically relevant antibiotics, such as methicillin, is increasing; furthermore, there has been an increase in the number of methicillin-resistant S. aureus community-acquired infections. Effective treatment and prevention strategies are urgently needed. We investigated the potential of the S. aureus surface protein iron surface determinant B (IsdB) as a prophylactic vaccine against S… CONTINUE READING

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Identification of a novel iron regulated staphylococcal surface protein with haptoglobin-haemoglobin binding activity

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