A novel STAT inhibitor, OPB-31121, has a significant antitumor effect on leukemia with STAT-addictive oncokinases

@inproceedings{Hayakawa2013ANS,
  title={A novel STAT inhibitor, OPB-31121, has a significant antitumor effect on leukemia with STAT-addictive oncokinases},
  author={Fumihiko Hayakawa and Keiki Sugimoto and Yoshimitsu Harada and Naohiro Hashimoto and Norihito Ohi and Shingo Kurahashi and Tomoki Naoe},
  booktitle={Blood cancer journal},
  year={2013}
}
Signal transduction and activator of transcription (STAT) proteins are extracellular ligand-responsive transcription factors that mediate cell proliferation, apoptosis, differentiation, development and the immune response. Aberrant signals of STAT induce uncontrolled cell proliferation and apoptosis resistance and are strongly involved in cancer. STAT has been identified as a promising target for antitumor drugs, but to date most trials have not been successful. Here, we demonstrated that a… CONTINUE READING
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