A novel ROCK inhibitor, Y-39983, promotes regeneration of crushed axons of retinal ganglion cells into the optic nerve of adult cats.

@article{Sagawa2007ANR,
  title={A novel ROCK inhibitor, Y-39983, promotes regeneration of crushed axons of retinal ganglion cells into the optic nerve of adult cats.},
  author={Hiroe Sagawa and Hiroko Terasaki and Makoto Nakamura and Masahiro Ichikawa and Takayuki Yata and Yoshihito Tokita and Masami Watanabe},
  journal={Experimental neurology},
  year={2007},
  volume={205 1},
  pages={230-40}
}
We investigated the effect of a novel ROCK inhibitor, Y-39983, on neurite regeneration in vitro and axonal regeneration in the crushed cat optic nerve in vivo. To determine the effective dose for neurite regeneration, retinal pieces were cultured with ROCK inhibitors, Y-39983 or Y-27632, a well-characterized ROCK inhibitor, and the number and length of TUJ-1-positive neurites were evaluated. The greatest number of neurites protruded at a dose of 3-10 microM Y-39983 and at a dose of 10-100… CONTINUE READING