A novel RNA polymerase I-dependent RNase activity that shortens nascent transcripts from the 3' end.

@article{Tschochner1996ANR,
  title={A novel RNA polymerase I-dependent RNase activity that shortens nascent transcripts from the 3' end.},
  author={Herbert Tschochner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 23},
  pages={12914-9}
}
A novel RNase activity was identified in a yeast RNA polymerase I (pol I) in vitro transcription system. Transcript cleavage occurred at the 3' end and was dependent on the presence of ternary pol I/DNA/RNA complexes and an additional protein factor not identical to transcription factor IIS (TFIIS). Transcript cleavage was observed both on arrested complexes at the linearized ends of the transcribed DNA and on intrinsic blocks of the DNA template. Shortened transcripts that remained associated… CONTINUE READING

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