A novel RNA motif that binds efficiently and specifically to the Ttat protein of HIV and inhibits the trans-activation by Tat of transcription in vitro and in vivo.

@article{Yamamoto2000ANR,
  title={A novel RNA motif that binds efficiently and specifically to the Ttat protein of HIV and inhibits the trans-activation by Tat of transcription in vitro and in vivo.},
  author={Ryuji Yamamoto and Masato Katahira and S. Nishikawa and Tomoya Baba and Kazunari Taira and Penmetcha K R Kumar},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  year={2000},
  volume={5 5},
  pages={371-88}
}
BACKGROUND To find a novel RNA that would bind efficiently and specifically to Tat protein but not to other cellular factors, we used an in vitro selection method and isolated a novel aptamer RNATat, a 37-mer RNA oligomer, that binds efficiently to the Tat protein of HIV-1. In the present study, we analysed various properties of aptamer RNATat, including… CONTINUE READING