A novel RET inhibitor with potent efficacy against medullary thyroid cancer in vivo.

@article{Samadi2010ANR,
  title={A novel RET inhibitor with potent efficacy against medullary thyroid cancer in vivo.},
  author={Abbas K. Samadi and Ridhwi Mukerji and Anuj Shah and Barbara N. Timmermann and Mark S. Cohen},
  journal={Surgery},
  year={2010},
  volume={148 6},
  pages={1228-36; discussion 1236}
}
BACKGROUND Most medullary thyroid carcinomas (MTC) recur or progress despite curative resection. Current targeted therapies show promise but lack durable efficacy and tolerability. The purpose of this study was to build on previous in vitro work and evaluate withaferin A (WA), a novel RET inhibitor, in a metastatic murine model of MTC. METHODS A total of 5 million DRO-81-1 human MTC cells injected in the left posterior neck of nu/nu mice generated metastases uniformly to the liver, spleen… CONTINUE READING

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