A novel PPARgamma agonist, KR62776, suppresses RANKL-induced osteoclast differentiation and activity by inhibiting MAP kinase pathways.

@article{Park2009ANP,
  title={A novel PPARgamma agonist, KR62776, suppresses RANKL-induced osteoclast differentiation and activity by inhibiting MAP kinase pathways.},
  author={Ju-Young Park and Myung-Ae Bae and Hyae Gyeong Cheon and Sung Soo Kim and J. M. Hong and Tae-Ho Kim and J. -H. Choi and Sang Hyun Kim and Jiwon Lim and Chang-Hyuk Choi and Hong-in Shin and Shin-Yoon Kim and Eui Kyun Park},
  journal={Biochemical and biophysical research communications},
  year={2009},
  volume={378 3},
  pages={645-9}
}
We investigated the effects of a novel peroxisome proliferator-activated receptor gamma (PPARgamma) agonist, KR62776, on osteoclast differentiation and function, and on the underlying signaling pathways. KR62776 markedly suppressed differentiation into osteoclasts in various osteoclast model systems, including bone marrow mononuclear (BMM) cells and a co-culture of calvarial osteoblasts and BMM cells. KR62776 suppressed the activation of tartrate-resistant acid phosphatase (TRAP) and the… CONTINUE READING
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