A novel PPAR response element in the murine iNOS promoter.

  title={A novel PPAR response element in the murine iNOS promoter.},
  author={Michelle B Crosby and John L Svenson and Gary S. Gilkeson and Tamara K Nowling},
  journal={Molecular immunology},
  volume={42 11},
The nuclear hormone receptor peroxisome proliferation activated receptor gamma (PPARgamma) is a modulator of inflammation including down-regulation of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production. PPARgamma agonists reduce iNOS expression and NO production in a dose-dependent manner in macrophages, mesangial cells and other inflammatory cells. However, the mechanisms involved in the inhibition of iNOS expression by PPARgamma and its agonists are not fully understood… CONTINUE READING

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