A novel PNET cell line with melanotic differentiation.

Abstract

The primitive neuroectodermal tumor (PNET) cell line, ONS-99, was established from a human melanotic neuroectodermal tumor of infancy (MNTI). ONS-99 cells were polygonal adherent cells and transplantable to BALB/c-nu/nu mouse. ONS-99 cells were positive for NSE, HMB-45 (melanoma-associated antigen) and N-myc, but lacked the antigenic features of terminally differentiated neurons or glias. ONS-99 cells had many intermediate filaments in the cytoplasm and tight intercellular junctions with scant cytoplasmic structures by electron microscopy. To date, ONS-99 is the only example of an established PNET cell line with melanotic differentiation.

Cite this paper

@article{Moriuchi1996ANP, title={A novel PNET cell line with melanotic differentiation.}, author={Shusuke Moriuchi and Katsuyoshi Shimizu and Yasuyoshi Miyao and Toru Hayakawa}, journal={Anticancer research}, year={1996}, volume={16 2}, pages={779-84} }