A novel PET protocol for visualization of breast cancer resistance protein function at the blood-brain barrier.


Breast cancer resistance protein (BCRP) is the most abundant multidrug efflux transporter at the human blood-brain barrier (BBB), restricting brain distribution of various drugs. In this study, we developed a positron emission tomography (PET) protocol to visualize Bcrp function at the murine BBB, based on the dual P-glycoprotein (P-gp)/Bcrp substrate… (More)
DOI: 10.1038/jcbfm.2012.112