A novel PAAD-containing protein that modulates NF-kappa B induction by cytokines tumor necrosis factor-alpha and interleukin-1beta.

@article{Fiorentino2002ANP,
  title={A novel PAAD-containing protein that modulates NF-kappa B induction by cytokines tumor necrosis factor-alpha and interleukin-1beta.},
  author={Loredana Fiorentino and Christian Stehlik and Vasco A. Oliveira and Maria Eugenia Ariza and Adam Godzik and John C. Reed},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 38},
  pages={35333-40}
}
PAAD domains are found in diverse proteins of unknown function and are structurally related to a superfamily of protein interaction modules that includes death domains, death effector domains, and Caspase activation and recruitment domains. Using bioinformatics strategies, cDNAs were identified that encode a novel protein of 110 kDa containing a PAAD domain followed by a putative nucleotide-binding (NACHT) domain and several leucine-rich repeat domains. This protein thus resembles Cryopyrin, a… CONTINUE READING

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