A novel NOD-derived murine model of primary Sjögren's syndrome.

@article{Robinson1998ANN,
  title={A novel NOD-derived murine model of primary Sj{\"o}gren's syndrome.},
  author={Christine Mary Pemberton Robinson and Shigeo Yamachika and Denise Ida Bounous and James Brayer and Roland Jonsson and Rikard Holmdahl and Ammon Broughton Peck and Michael G. Humphreys-Beher},
  journal={Arthritis and rheumatism},
  year={1998},
  volume={41 1},
  pages={
          150-6
        }
}
OBJECTIVE The appearance of autoimmune diabetes prior to autoimmune exocrinopathy in the NOD mouse suggests that it is an excellent model of secondary, but not primary, autoimmune sicca complications. Since the unique major histocompatibility complex (MHC) I-A(g7) expression in NOD mice is essential for the development of insulitis and diabetes in these animals, we investigated exocrine gland function in NOD.B10.H2b mice, which have an MHC congenic to NOD, as a potential model for primary Sj… CONTINUE READING
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