A novel NADH-dependent and FAD-containing hydroxylase is crucial for nicotine degradation by Pseudomonas putida.

@article{Tang2011ANN,
  title={A novel NADH-dependent and FAD-containing hydroxylase is crucial for nicotine degradation by Pseudomonas putida.},
  author={Hongzhi Tang and Yuxiang Yao and Dake Zhang and Xiangzhou Meng and Lijuan Wang and Hao Yu and Lanying Ma and Ping Xu},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 45},
  pages={39179-87}
}
Nicotine, the main alkaloid produced by Nicotiana tabacum and other Solanaceae, is very toxic and may be a leading toxicant causing preventable disease and death, with the rise in global tobacco consumption. Several different microbial pathways of nicotine metabolism have been reported: Arthrobacter uses the pyridine pathway, and Pseudomonas, like mammals, uses the pyrrolidine pathway. We identified and characterized a novel 6-hydroxy-3-succinoyl-pyridine (HSP) hydroxylase (HspB) using enzyme… CONTINUE READING
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Molecular cloning: A laboratory manual, 3 ed

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  • Cold Spring Harbor Laboratory
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