A novel N-terminal degradation reaction of peptides via N-amidination.

  title={A novel N-terminal degradation reaction of peptides via N-amidination.},
  author={Yoshio Hamada},
  journal={Bioorganic & medicinal chemistry letters},
  volume={26 7},
The cleavage of amide bonds requires considerable energy. It is difficult to cleave the amide bonds in peptides at room temperature, whereas ester bonds are cleaved easily. If peptide bonds can be selectively cleaved at room temperature, it will become a powerful tool for life science research, peptide prodrug, and tissue-targeting drug delivery systems. To cleave a specific amide bond at room temperature, the decomposition reaction of arginine methyl ester was investigated. Arginine methyl… CONTINUE READING


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Amino Acids, Peptides and Proteins; Royal Society of Chemistry: London, 2015; Vol

Y. Hamada, Y. Kiso


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