A novel N-alkylated prodigiosin analogue induced death in tumour cell through apoptosis or necrosis depending upon the cell type

Abstract

To investigate the mechanism of cell death induced by the N-alkylated prodigiosin analogue, 2,2′-[3-methoxy-1′amyl-5′-methyl-4-(1′′-pyrryl)] dipyrryl-methene (MAMPDM) in S-180 and EL-4 tumour cell lines. Effect of MAMPDM on cell viability was assessed by MTT dye conversion. Induction of apoptosis was assessed by monitoring caspase 3 activity using a… (More)
DOI: 10.1007/s00280-007-0475-y

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@article{Deorukhkar2007ANN, title={A novel N-alkylated prodigiosin analogue induced death in tumour cell through apoptosis or necrosis depending upon the cell type}, author={Amit A. Deorukhkar and Ramesh Chander and Ruchi Pandey and Krishna Balaji Sainis}, journal={Cancer Chemotherapy and Pharmacology}, year={2007}, volume={61}, pages={355-363} }