A novel N-acetyl-glucosamine lectin of Lonchocarpus araripensis attenuates acute cellular inflammation in mice

@article{Pires2015ANN,
  title={A novel N-acetyl-glucosamine lectin of Lonchocarpus araripensis attenuates acute cellular inflammation in mice},
  author={Alana de Freitas Pires and Nat{\'a}lia Velloso Fontenelle Camelo Rodrigues and Pedro Marcos Gomes Soares and Ronaldo A. Ribeiro and Karoline Sab{\'o}ia Arag{\~a}o and M{\'a}rcia Machado Marinho and Mayara Cristina Pinto da Silva and Benildo Sousa Cavada and Ana Maria Sampaio Assreuy},
  journal={Inflammation Research},
  year={2015},
  volume={65},
  pages={43-52}
}
AbstractObjective and design This study had investigated the anti-inflammatory activity of a seed lectin (LAL) isolated from Lonchocarpus araripensis.Material/methodsLAL was purified by affinity chromatography (chitin column) and ion exchange chromatography (DEAE-Sephacel). In vitro LAL was tested for hemagglutinating activity against rabbit erythrocytes. In vivo LAL was assessed for the anti-inflammatory activity via intravenous injection (i.v.) in Swiss mice (25–30 g; n = 6/group) in models… 
Inhibitory effect of Lonchocarpus araripensis lectin in rat acute models of inflammation.
TLDR
LAL possesses anti-inflammatory effect via lectin domain, indicating potential modulator role in cellular inflammatory events in rat models of acute inflammation.
Inhibition of Carrageenan-Induced Acute Inflammation in Mice by the Microgramma vacciniifolia Frond Lectin (MvFL)
TLDR
Evaluating the effects of MvFL on the in vivo inflammatory status in the carrageenan-induced peritonitis and paw edema using female Swiss mice showed inhibitory effects in in vivo acute inflammation, which encouraged future studies exploiting its immunomodulatory ability.
Antinociceptive effect of Lonchocarpus araripensis lectin: activation of l-arginine/NO/cGMP/K+ATP signaling pathway
TLDR
LAL increased (95%) nNOS gene expression in mice paw tissues, but not its immunoexpression in the dorsal root ganglia, and LAL effect was reversed by nifedipine, niflumic acid, and glibenclamide, but was unaltered by aminoguanidine.
Antinociceptive and Anti‐Inflammatory Effects of Saline Extract and Lectin‐Rich Fraction from Microgramma vacciniifolia Rhizome in Mice
TLDR
The substances investigated in this study can be used for the development of novel therapeutic options for pain and inflammatory processes.
Structural studies and nociceptive activity of a native lectin from Platypodium elegans seeds (nPELa).
The Antinociceptive Effect of Lonchocarpus Araripensis Lectin is Mediated by Endocannabinoid Receptors
TLDR
The involvement of endocannabinoid receptors in the antinociceptive activity of Lonchocarpus araripensis lectin was investigated in the model of carragenan-induced hypernociception and reversed the inhibitory effect of LAL.
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