A novel N-acetyl-glucosamine lectin of Lonchocarpus araripensis attenuates acute cellular inflammation in mice

@article{Pires2015ANN,
  title={A novel N-acetyl-glucosamine lectin of Lonchocarpus araripensis attenuates acute cellular inflammation in mice},
  author={Alana de Freitas Pires and Nat{\'a}lia Velloso Fontenelle Camelo Rodrigues and Pedro Marcos Gomes Soares and Ronaldo A. Ribeiro and Karoline Sab{\'o}ia Arag{\~a}o and M{\'a}rcia Machado Marinho and Mayara Cristina Pinto da Silva and Benildo Sousa Cavada and Ana Maria Sampaio Assreuy},
  journal={Inflammation Research},
  year={2015},
  volume={65},
  pages={43-52}
}
AbstractObjective and design This study had investigated the anti-inflammatory activity of a seed lectin (LAL) isolated from Lonchocarpus araripensis.Material/methodsLAL was purified by affinity chromatography (chitin column) and ion exchange chromatography (DEAE-Sephacel). In vitro LAL was tested for hemagglutinating activity against rabbit erythrocytes. In vivo LAL was assessed for the anti-inflammatory activity via intravenous injection (i.v.) in Swiss mice (25–30 g; n = 6/group) in models… 
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Inhibitory effect of Lonchocarpus araripensis lectin in rat acute models of inflammation.
TLDR
LAL possesses anti-inflammatory effect via lectin domain, indicating potential modulator role in cellular inflammatory events in rat models of acute inflammation.
Lectin purified from Lonchocarpus campestris seeds inhibits inflammatory nociception.
Lectin obtained from the red seaweed Bryothamnion triquetrum: Secondary structure and anti-inflammatory activity in mice.
Contribution of the carbohydrate-binding ability of Vatairea guianensis lectin to induce edematogenic activity.
Inhibition of Carrageenan-Induced Acute Inflammation in Mice by the Microgramma vacciniifolia Frond Lectin (MvFL)
TLDR
Evaluating the effects of MvFL on the in vivo inflammatory status in the carrageenan-induced peritonitis and paw edema using female Swiss mice showed inhibitory effects in in vivo acute inflammation, which encouraged future studies exploiting its immunomodulatory ability.
Structural analysis, molecular docking and molecular dynamics of an edematogenic lectin from Centrolobium microchaete seeds.
Antinociceptive effect of Lonchocarpus araripensis lectin: activation of l-arginine/NO/cGMP/K+ATP signaling pathway
TLDR
LAL increased (95%) nNOS gene expression in mice paw tissues, but not its immunoexpression in the dorsal root ganglia, and LAL effect was reversed by nifedipine, niflumic acid, and glibenclamide, but was unaltered by aminoguanidine.
Antinociceptive and Anti‐Inflammatory Effects of Saline Extract and Lectin‐Rich Fraction from Microgramma vacciniifolia Rhizome in Mice
TLDR
The substances investigated in this study can be used for the development of novel therapeutic options for pain and inflammatory processes.
Structural studies and nociceptive activity of a native lectin from Platypodium elegans seeds (nPELa).
The Antinociceptive Effect of Lonchocarpus Araripensis Lectin is Mediated by Endocannabinoid Receptors
TLDR
The involvement of endocannabinoid receptors in the antinociceptive activity of Lonchocarpus araripensis lectin was investigated in the model of carragenan-induced hypernociception and reversed the inhibitory effect of LAL.
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References

SHOWING 1-10 OF 30 REFERENCES
Purification and partial characterization of a new pro-inflammatory lectin from Bauhinia bauhinioides Mart (Caesalpinoideae) seeds.
TLDR
Findings indicate that BBL can be used as a tool to better understand the mechanisms involved in inflammatory responses and that nitric oxide participation in the late phase of the edema is important.
Anti-inflammatory effect of glucose—mannose binding lectins isolated from Brazilian beans
TLDR
It is speculated that the plant lectin antiinflammatory activity is probably due to a competitive blockage of a common leukocyte and/or endothelial selectin carbohydrate ligand.
Vasodilator effects of Diocleinae lectins from the Canavalia genus
TLDR
Important vasodilator effects of different degrees and mechanisms in vivo and in vitro of Canavalia lectins are demonstrated.
Vatairea macrocarpa (Leguminosae) lectin activates cultured macrophages to release chemotactic mediators
TLDR
The data suggest that neutrophil migration induced by V. macrocarpa lectin occurs via the release of cytokines such as TNF-α by macrophages, and this lectin may represent an important tool to better understand pathological situations where an excess of leukocytes at inflammatory sites causes tissue injury.
Anti‐inflammatory and antimicrobial effect of lectin from Lonchocarpus sericeus seeds in an experimental rat model of infectious peritonitis
TLDR
Treatment with LSL inhibited the inflammatory response and the bacterial colonization of infectious peritonitis in rats and promoted a marked decrease of the viable bacterial population in peritoneal cavities.
Lectin extracted from Canavalia grandiflora seeds presents potential anti-inflammatory and analgesic effects
TLDR
It is demonstrated that the lectin ConGF inhibits neutrophil migration and mechanical inflammatory hypernociception.
Antinociceptive and anti-inflammatory effects of a mucin-binding agglutinin isolated from the red marine alga Hypnea cervicornis
TLDR
H. cervicornis agglutinin showed important antinociceptive and anti-inflamatory activity via interaction with the lectin carbohydrate-binding site in models of nociception and inflammation.
Leguminous lectins as tools for studying the role of sugar residues in leukocyte recruitment.
TLDR
An important role is suggested for N-acetylglucosamine residue as the major ligand for selectins on rat neutrophil membranes in the face of peritonitis and paw oedema models induced by carrageenin in rats.
Effects of Canavalia lectins on Acute Inflammation in Sensitized and Non-sensitized Rats
TLDR
ConM and CGL are anti- inflammatory, mainly in cellular events mediated by prostaglandin E2, nitric oxide and TNF-α in non-sensitized rats, however, only ConM is anti-inflammatory in sensitized rats.
Purification and primary structure of a mannose/glucose‐binding lectin from Parkia biglobosa Jacq. seeds with antinociceptive and anti‐inflammatory properties
TLDR
Parkia biglobosa lectin (PBL) strongly agglutinated rabbit erythrocytes and showed important antinociceptive activity associated to the inhibition of inflammatory process.
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