A novel MyD-1 ( SIRP-1 ) signaling pathway that inhibits LPS-induced TNF production by monocytes

@inproceedings{Smith2003ANM,
  title={A novel MyD-1 ( SIRP-1 ) signaling pathway that inhibits LPS-induced TNF production by monocytes},
  author={Rosemary A. E. Smith and Vanshree Patel and Sandra D. Seatter and Maureen R. Deehan and Marion H Brown and Gareth P. Brooke and Helen S. Goodridge and Christopher J Howard and Kevin P. Rigley and W Harnett and Margaret M Harnett},
  year={2003}
}
MyD-1 (CD172) is a member of the family of signal regulatory phosphatase (SIRP) binding proteins, which is expressed on human CD14 monocytes and dendritic cells. We now show a novel role for MyD-1 in the regulation of the innate immune system by pathogen products such as lipopolysaccharide (LPS), purified protein derivative (PPD), and Zymosan. Specifically, we demonstrate that ligation of MyD-1 on peripheral blood mononuclear cells (PBMCs) inhibits tumor necrosis factor alpha (TNF ) secretion… CONTINUE READING

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