A novel Mn++-dependent ribonuclease that functions in U16 SnoRNA processing in X. laevis.

@article{Caffarelli1997ANM,
  title={A novel Mn++-dependent ribonuclease that functions in U16 SnoRNA processing in X. laevis.},
  author={Elisa Caffarelli and Lino Maggi and Alessandro Fatica and Joseph Jiricny and Irene Bozzoni},
  journal={Biochemical and biophysical research communications},
  year={1997},
  volume={233 2},
  pages={514-7}
}
The intron-encoded U16 small nucleolar RNA (snoRNA) is a component of a new family of molecules which originate by processing of pre-mRNA in which they are contained. The mechanism of U16 snoRNA biosynthesis involves an initial step of endonucleolytic cleavage of the pre-mRNA with the release of a pre-snoRNA molecule; the subsequent step consists of exonucleolytic trimming that produces mature U16 molecules. In order to identify the molecular components involved in this peculiar biosynthetic… CONTINUE READING

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