A novel MKRN3 nonsense mutation causing familial central precocious puberty.


Central or gonadotropin-dependent precocious puberty (CPP) caused by early activation of pulsatile Gonadotropinreleasing hormone (GnRH) secretion is clinically defined by the early maturation of the entire hypothalamic-pituitarygonadal axis and the development of secondary sexual characteristics before the age of 8 years in girls and 9 years in boys [1… (More)
DOI: 10.1007/s12020-017-1232-6


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