A novel MCP-1 gene polymorphism is associated with hepatic MCP-1 expression and severity of HCV-related liver disease.

@article{Muehlbauer2003ANM,
  title={A novel MCP-1 gene polymorphism is associated with hepatic MCP-1 expression and severity of HCV-related liver disease.},
  author={Marcus Muehlbauer and Anja Katrin Bosserhoff and Arndt Hartmann and Wolfgang E. Thasler and Thomas S. Weiss and Hans Herfarth and Guntram Lock and Juergen Schoelmerich and Claus Hellerbrand},
  journal={Gastroenterology},
  year={2003},
  volume={125 4},
  pages={1085-93}
}
BACKGROUND AND AIMS Factors influencing the progression of chronic hepatitis C virus (HCV) infection are poorly understood. Monocyte chemotactic protein-1 (MCP-1) is a potent chemokine, and its hepatic expression is up-regulated during chronic HCV infection mainly in activated hepatic stellate cells (HSC). In this study, we investigated the correlation of the functional -2518 MCP-1 promoter polymorphism with hepatic MCP-1 expression and the disease outcome in patients with HCV. METHODS MCP-1… CONTINUE READING

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