A novel K+ current inhibited by adrenocorticotropic hormone and angiotensin II in adrenal cortical cells.

@article{Mlinar1993ANK,
  title={A novel K+ current inhibited by adrenocorticotropic hormone and angiotensin II in adrenal cortical cells.},
  author={B Mlinar and Bruce A. Biagi and Judith A. Enyeart},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 12},
  pages={8640-4}
}
Adrenocorticotropic hormone (ACTH) and angiotensin II (AII) are peptides that regulate the production of steroid hormones by cells of the adrenal cortex. The cellular mechanisms linking these peptides to corticosteroid hormone secretion are not understood. In patch clamp recordings from bovine adrenal zona fasciculata (AZF) cells, we have identified a novel cholera toxin-sensitive K+ current (IAC), which is potently inhibited by both ACTH and AII with respective EC50 values of 4.5 and 145 pM… CONTINUE READING
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