A novel Hsp90 inhibitor AT13387 induces senescence in EBV-positive nasopharyngeal carcinoma cells and suppresses tumor formation

Abstract

Nasopharyngeal carcinoma (NPC) is an epithelial malignancy strongly associated with Epstein-Barr virus (EBV). AT13387 is a novel heat shock protein 90 (Hsp90) inhibitor, which inhibits the chaperone function of Hsp90 and reduces expression of Hsp90-dependent client oncoproteins. This study aimed to evaluate both the in vitro and in vivo antitumor effects of… (More)
DOI: 10.1186/1476-4598-12-128

Topics

6 Figures and Tables

Cite this paper

@inproceedings{Chan2013ANH, title={A novel Hsp90 inhibitor AT13387 induces senescence in EBV-positive nasopharyngeal carcinoma cells and suppresses tumor formation}, author={King Chan and Choi Man Ting and Pui Shan Julia Chan and Ming Lo and Kwok-Wai Lo and Jayne E. Curry and Tomoko Smyth and Anne Wing Mui Lee and Wai Tong Ng and George Sai Wah Tsao and Ricky Wong and Maria Li Lung and Nai-ki Mak}, booktitle={Molecular Cancer}, year={2013} }