# A novel HLA-DRβI sequence from the DRw11 haplotype

@article{Steimle2004ANH,
title={A novel HLA-DR$\beta$I sequence from the DRw11 haplotype},
author={V. Steimle and A. Hinkkanen and M. Schlesier and J. Epplen},
journal={Immunogenetics},
year={2004},
volume={28},
pages={208-210}
}
The most striking feature of major histocompatibility complex (MHC)-encoded molecules is their extensive variability (for a thorough review see Klein 1986). The interaction of MHC proteins with T cells during antigen presentation and recognition is crucial for the course of the immune response (Klein 1986). The heterodimeric HLA-DR molecules are the most abundantly expressed MHC class II molecules in man. Their high degree of polymorphism is entirely due to the variability of the DR~ chains… Expand
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#### Tables from this paper

The antigen receptor of an autoreactive T-cell clone from human rheumatic synovia
• Biology, Medicine
• Immunogenetics
• 2004
The functional characterization of the autoreactive Tcc UA-S2 (CD4+8 -) revealed that probably the HLA class II antigen DRwl 1 is exclusively recognized and the DNA sequence analysis of the Hla-DRB1*11 gene showed a novel composition. Expand
Unique sequences for two HLA-DRB1 genes expressed on distinct DRw6 haplotypes
The results of this study suggest that the DRw52 family haplotypes is derived from a relatively restricted number of ancestral sequences, with diversity among DRB1 alleles within this family arising through gene conversion or recombination events. Expand
Nomenclature for factors of the HLA system, 1989
• Medicine
• Immunogenetics
• 2004
This report concerns only the naming of new alleles and loci defined by nucleotide or inferred amino acid sequences in the HLA region, and includes the new genes named for the first time in this report. Expand
Nomenclature for factors of the HLA system, 1989.

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