A novel HLA-DRβI sequence from the DRw11 haplotype

@article{Steimle2004ANH,
  title={A novel HLA-DR$\beta$I sequence from the DRw11 haplotype},
  author={V. Steimle and A. Hinkkanen and M. Schlesier and J. Epplen},
  journal={Immunogenetics},
  year={2004},
  volume={28},
  pages={208-210}
}
The most striking feature of major histocompatibility complex (MHC)-encoded molecules is their extensive variability (for a thorough review see Klein 1986). The interaction of MHC proteins with T cells during antigen presentation and recognition is crucial for the course of the immune response (Klein 1986). The heterodimeric HLA-DR molecules are the most abundantly expressed MHC class II molecules in man. Their high degree of polymorphism is entirely due to the variability of the DR~ chains… Expand
4 Citations

Tables from this paper

The antigen receptor of an autoreactive T-cell clone from human rheumatic synovia
TLDR
The functional characterization of the autoreactive Tcc UA-S2 (CD4+8 -) revealed that probably the HLA class II antigen DRwl 1 is exclusively recognized and the DNA sequence analysis of the Hla-DRB1*11 gene showed a novel composition. Expand
Unique sequences for two HLA-DRB1 genes expressed on distinct DRw6 haplotypes
TLDR
The results of this study suggest that the DRw52 family haplotypes is derived from a relatively restricted number of ancestral sequences, with diversity among DRB1 alleles within this family arising through gene conversion or recombination events. Expand
Nomenclature for factors of the HLA system, 1989
TLDR
This report concerns only the naming of new alleles and loci defined by nucleotide or inferred amino acid sequences in the HLA region, and includes the new genes named for the first time in this report. Expand
Nomenclature for factors of the HLA system, 1989.

References

SHOWING 1-10 OF 15 REFERENCES
Sequence polymorphism of HLA DRβ1 alleles relating to T-cell-recognized determinants
TLDR
Comparisons of sequences of three HLA DRβ cDNA clones obtained from cells that all express the same serologically defined determinants but differ in terms of T-cell-recognized specificities indicate that very few nucleotides differ between what are almost certainly alleles of the DRβ1 locus. Expand
Complete characterization and sequence of an HLA class II DR beta chain cDNA from the DR5 haplotype.
TLDR
A cDNA library was constructed from the Swei cell line homozygous for the DR5 haplotype, and a beta chain clone was isolated, characterized, and sequenced, supporting the notion of gene conversion as an evolutionary mechanism generating polymorphism. Expand
Allelic variation in the DR subregion of the human major histocompatibility complex.
TLDR
Allelic variation in the DR subregion of the human major histocompatibility complex has been analyzed by nucleic acid sequencing of cDNA clones obtained from cell lines homozygous by consanguinity for all the common serological types DR1-9, confirming the presence of three allelic hypervariable regions. Expand
Generation of Class II Antigen Polymorphism
TLDR
Observed observations suggest that the low frequencies even of the most prevalent alleles in outbred populations render homozygosity at the MHC loci uncommon, and suggest that evolution has not grossly favored any single allele over the others. Expand
Linkage map of three HLA-DR beta-chain genes: evidence for a recent duplication event.
  • P. Rollini, B. Mach, J. Gorski
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1985
TLDR
A striking restriction site homology has been found within the DR beta-chain gene cluster, suggesting a recent duplication event involving at least 25 kilobases of DNA. Expand
Antigen Report: HLA-DR5 and Its Subtypes HLA-DRw11 and HLA-DRw12
TLDR
Difficulty in the distinction of DR5 from DRw6 and DRw8-related specificities led us to analyze several groups of sera differentiating these specificities, and the segregation pattern of the sera mentioned in Table 1 were studied in informative families. Expand
Mutations and selection in the generation of class II histocompatibility antigen polymorphism.
TLDR
The results suggest that the mutation rates are of a comparable magnitude in the nucleotide sequences encoding the first and second external domains of the class II molecules, Nevertheless, the allelic amino acid replacements are predominantly located in the first domains. Expand
Identification and distribution of three serologically undetected alleles of HLA-DR by oligonucleotide.DNA typing analysis.
TLDR
Analysis of this micropolymorphism detected at the DNA sequence level can easily be analyzed by hybridization with allele-specific oligonucleotides (HLA "oligotyping") and is therefore now operational for more accurate HLA matching for transplantation and for improving correlations between HLA and disease susceptibility. Expand
Polymorphism of human Ia antigens: gene conversion between two DR β loci results in a new HLA-D/DR specificity
TLDR
The generation of HLA-DR polymorphism within the DRw52 supertypic group can thus be accounted for by a succession of gene duplication, divergence and gene conversion. Expand
Structural comparison of the genes of two HLA-DR supertypic groups: The loci encoding DRw52 and DRw53 are not truly allelic
TLDR
The organization and sequence of the HLA-DRβ chain genes are compared in the two supertypic groups, DRw52 and DRw53, and it is evident that the differentHLA-DR alleles are not structurally equidistant and that one must take into consideration different degrees of heterozygosity or mismatch among the DR alleles. Expand
...
1
2
...