A novel G protein-coupled receptor mediating both vasopressin- and oxytocin-like functions of Lys-conopressin in Lymnaea stagnalis

@article{Kesteren1995ANG,
  title={A novel G protein-coupled receptor mediating both vasopressin- and oxytocin-like functions of Lys-conopressin in Lymnaea stagnalis},
  author={Ronald E. van Kesteren and Cornelis P. Tensen and August Benjamin Smit and J. H. van Minnen and Paul F. van Soest and Karel S. Kits and Wolfgang Meyerhof and Dietmar Richter and Harm van Heerikhuizen and Erno Vreugdenhil and Wijnand P. M. Geraerts},
  journal={Neuron},
  year={1995},
  volume={15},
  pages={897-908}
}
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Co-evolution of Ligand-Receptor Pairs in the Vasopressin/Oxytocin Superfamily of Bioactive Peptides (*)
TLDR
A theory of the molecular co-evolution of the functionally distinct ligand-receptor pairs of the vasopressin/oxytocin superfamily of bioactive peptides is provided.
Vasopressin/oxytocin-related conopressin induces two separate pacemaker currents in an identified central neuron of Lymnaea stagnalis.
TLDR
The results suggest that two distinct conopressin receptors are involved in the activation of both currents, and induce or enhance a region of negative slope resistance in the steady-state current-voltage relation.
Activation of protein kinase C by oxytocin-related conopressin underlies pacemaker current in Lymnaea central neurons.
TLDR
It is concluded that conopressin activates the ion channels carrying I(LVA) and I (HVA) through different second-messenger cascades and that PKC-dependent phosphorylation underlies activation of I(HVA).
The Lymnaea Cardioexcitatory Peptide (LyCEP) Receptor: A G-Protein–Coupled Receptor for a Novel Member of the RFamide Neuropeptide Family
TLDR
Data confirm that LyCEP is an RFamide ligand for GRL106, and shows significant similarity to the Achatina cardioexcitatory peptide as well as to the recently identified family of mammalian prolactin-releasing peptides.
Identification of a novel receptor for an invertebrate oxytocin/vasopressin superfamily peptide: molecular and functional evolution of the oxytocin/vasopressin superfamily.
TLDR
The identification of an endogenous AnR (annetocin receptor) and the first description concerning the functional correlation between an invertebrate OT/VP-related peptide and egg-laying behaviour are described.
Cloning, expression and pharmacological characterization of a vasopressin-related receptor in an annelid, the leech Theromyzon tessulatum.
TLDR
The characterization of a novel AVP/OT superfamily receptor in annelids is described, which is considered the most distant group of coelomate metazoans possessing a functional A VP/OT-related endocrine system.
Cloning , expression and pharmacological characterization of a vasopressin-related receptor in an annelid , the leech Theromyzon
TLDR
The characterization of a novel AVP/OT superfamily receptor in annelids is described, which is considered the most distant group of coelomate metazoans possessing a functional A VP/OT-related endocrine system.
Novel evolutionary lineages of the invertebrate oxytocin/vasopressin superfamily peptides and their receptors in the common octopus (Octopus vulgaris).
TLDR
The findings suggest that the CT and OP genes, similar to the OT/VP family, evolved through duplication, but the ligand-receptor selectivity were established through different evolutionary lineages from those of their vertebrate counterparts.
A vasopressin/oxytocin-related conopeptide with γ-carboxyglutamate at position 8
TLDR
NMR spectroscopy of the peptide isolated directly from the cone snails revealed that the native γ-conopressin-vil undergoes structural changes in the presence of calcium, which suggests that the peptides binds calcium, and the calcium-binding process is mediated by the ε-carboxyglutamate residue.
Role of Lys-Conopressin in the Control of Male Sexual Behavior in Lymnaea stagnalis
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TLDR
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TLDR
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