A novel FoxD3 Variant Is Associated With Vitiligo and Elevated Thyroid Auto-Antibodies.

  title={A novel FoxD3 Variant Is Associated With Vitiligo and Elevated Thyroid Auto-Antibodies.},
  author={Jo Ana Schunter and Dennis Loeffler and Tobias Wiesner and Peter Kovacs and Klaus Badenhoop and Gabriela Aust and Anke Toenjes and Peter Mueller and Ronny Baber and Jan C. Simon and D. J. Fuehrer and Roland W. Pf{\"a}ffle and Joachim Thiery and Michael Stumvoll and Wieland Kiess and J{\"u}rgen Kratzsch Kratzsch and Antje K{\"o}rner},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={100 10},
CONTEXT Vitiligo frequently coincides with autoimmune endocrinopathies, particularly Hashimoto's thyroiditis (HT). Genetic susceptibility may underlie this coincident occurrence. One candidate region is the autoimmunity susceptibility locus on chromosome 1, which encompasses forkhead transcription factor D3 (FoxD3), a gene involved in embryonal melanogenesis. We identified a promotor variant (rs78645479) in an index case of vitiligo + HT + candidiasis and evaluated its clinical and functional… CONTINUE READING
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