A novel Escherichia coli lipid A mutant that produces an antiinflammatory lipopolysaccharide.

@article{Somerville1996ANE,
  title={A novel Escherichia coli lipid A mutant that produces an antiinflammatory lipopolysaccharide.},
  author={John E. Somerville and L. C. M. Cassiano and Brian Bainbridge and Mark D. Cunningham and Richard Peters Darveau},
  journal={The Journal of clinical investigation},
  year={1996},
  volume={97 2},
  pages={359-65}
}
A unique screen was used to identify mutations in Escherichia coli lipid A biosynthesis that result in a decreased ability to stimulate E-selectin expression by human endothelial cells. A mutation was identified in the msbB gene of E. coli that resulted in lipopolysaccharide (LPS) that lacks the myristoyl fatty acid moiety of the lipid A. Unlike all previously reported lipid A mutants, the msbB mutant was not conditionally lethal for growth. Viable cells or purified LPS from an msbB mutant had… CONTINUE READING
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Escherichia coli genes encoding KDO dependent acyltransferases that incorporate laurate and myristate into Lipid A

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