A novel ELISA reveals high frequencies of BP180-specific IgE production in bullous pemphigoid.

@article{Messingham2009ANE,
  title={A novel ELISA reveals high frequencies of BP180-specific IgE production in bullous pemphigoid.},
  author={Kelly A Nordyke Messingham and Megan H. Noe and M. A. Chapman and George J. Giudice and Janet A. Fairley},
  journal={Journal of immunological methods},
  year={2009},
  volume={346 1-2},
  pages={
          18-25
        }
}
Bullous pemphigoid (BP) is a humoral autoimmune disease directed predominantly against the non-collagenous NC16A domain of the BP180 hemidesmosomal protein. Our laboratory has recently shown, using a mouse xenograft model, that passive transfer of IgE autoantibodies from BP sera induces a skin phenotype that recapitulates the early phases of the disease. Herein, we describe the development of a highly specific and sensitive ELISA to detect circulating IgE autoantibodies that recognize BP180… CONTINUE READING

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