A novel Drosophila Girdin-like protein is involved in Akt pathway control of cell size.

@article{Puseenam2009AND,
  title={A novel Drosophila Girdin-like protein is involved in Akt pathway control of cell size.},
  author={Aekkachai Puseenam and Yasuhide Yoshioka and Rika Nagai and Reina Hashimoto and Osamu Suyari and Masanobu Itoh and Atsushi Enomoto and Masahide Takahashi and Masamitsu Yamaguchi},
  journal={Experimental cell research},
  year={2009},
  volume={315 19},
  pages={3370-80}
}
The Akt signaling pathway is well known to regulate cell proliferation and growth. Girdin, a novel substrate of Akt, plays a crucial role in organization of the actin cytoskeleton and cell motility under the control of Akt. We here identified a novel Girdin-like protein in Drosophila (dGirdin), which has two isoforms, dGirdin PA and dGirdin PB. dGirdin shows high homology with human Girdin in the N-terminal and coiled-coil domains, while diverging at the C-terminal domain. On establishment of… CONTINUE READING