A novel DNA topoisomerase inhibitor: dehydroebriconic acid, one of the lanostane‐type triterpene acids from Poria cocos

@article{Mizushina2004AND,
  title={A novel DNA topoisomerase inhibitor: dehydroebriconic acid, one of the lanostane‐type triterpene acids from Poria cocos},
  author={Yoshiyuki Mizushina and Toshihiro Akihisa and Motohiko Ukiya and Chikako Murakami and Isoko Kuriyama and Xianai Xu and Hiromi Yoshida and Kengo Sakaguchi},
  journal={Cancer Science},
  year={2004},
  volume={95}
}
Traditional Chinese medicinal plants are a treasure house for screening novel inhibitors of DNA polymerases and DNA topoisomerases from mammals; in the present study, nine lanostanetype triterpene acids were found in sclerotium of Poria cocos. Among the nine compounds, only dehydroebriconic acid could potently inhibit DNA topoisomerase II (topo II) activity (IC50=4.6 μM), while the compound moderately inhibited the activities of DNA polymerases α, β, γ, δ, ɛ, η, iota;, κ and λ only from mammals… 
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