A novel C-terminal domain in the thyroid hormone receptor selectively mediates thyroid hormone inhibition.

@article{Flynn1994ANC,
  title={A novel C-terminal domain in the thyroid hormone receptor selectively mediates thyroid hormone inhibition.},
  author={Thomas R. Flynn and Anthony N. Hollenberg and Ofer Lider Cohen and Jan Menke and S J Usala and S R Tollin and Mary Hegarty and Fredric E. Wondisford},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 52},
  pages={32713-6}
}
Resistance to thyroid hormone (RTH) action is due to mutations in the beta-isoform of the thyroid hormone receptor (TR-beta). RTH patients display inappropriate central secretion of thyrotropin-releasing hormone (TRH) from the hypothalamus and thyrotropin (TSH) from the anterior pituitary in association with abnormal peripheral tissue responses to thyroid hormone. Whether TR-beta mutations cause a selective form of RTH, which only leads to abnormal pituitary TSH secretion (PRTH), is unclear. In… CONTINUE READING
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