A novel C₂₅ sterol peroxide from the endophytic fungus Phoma sp. EA-122.

Abstract

A novel C₂₅ sterol peroxide, phomasterol A (1), together with two known compounds (2-3), was isolated from the endophytic fungus Phoma sp. EA-122. The structure of phomasterol A (1) was elucidated by MS, 1D, and 2D NMR data analyses. Phomasterol A (1) was evaluated for its inhibitory activities against protein-tyrosine phosphatases MEG2 and PTP1Bc, showing moderate activities with identical IC₅₀ values of 25 μM.

DOI: 10.1515/znc-2014-4217

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Cite this paper

@article{Chen2015ANC, title={A novel C₂₅ sterol peroxide from the endophytic fungus Phoma sp. EA-122.}, author={Zi-ming Chen and Qiong-Ying Fan and He-ping Chen and Zheng-Hui Li and Tao Feng and Ji-kai Liu}, journal={Zeitschrift für Naturforschung. C, Journal of biosciences}, year={2015}, volume={70 3-4}, pages={93-6} }