A novel Bcr-Abl–mTOR–eIF4A axis regulates IRES-mediated translation of LEF-1

  title={A novel Bcr-Abl–mTOR–eIF4A axis regulates IRES-mediated translation of LEF-1},
  author={Becky Pinjou Tsai and Judith Jimenez and Sharon Xueqi Lim and Kerry D. Fitzgerald and Min Zhang and Charles T. H. Chuah and Haley D. Axelrod and L C Wilson and S. Tiong Ong and Bert L Semler and Marian L Waterman},
  booktitle={Open biology},
Internal ribosome entry sites (IRESs) in cellular mRNAs direct expression of growth-promoting factors through an alternative translation mechanism that has yet to be fully defined. Lymphoid enhancer factor-1 (LEF-1), a Wnt-mediating transcription factor important for cell survival and metastasis in cancer, is produced via IRES-directed translation, and its mRNA is frequently upregulated in malignancies, including chronic myeloid leukaemia (CML). In this study, we determined that LEF1 expression… CONTINUE READING
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High expression of lymphoid enhancer - binding factor - 1 ( LEF 1 ) is a novel favorable prognostic factor in cytogenetically normal acute myeloid leukemia

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