A novel BH3 mimetic reveals a mitogen-activated protein kinase-dependent mechanism of melanoma cell death controlled by p53 and reactive oxygen species.

@article{Verhaegen2006ANB,
  title={A novel BH3 mimetic reveals a mitogen-activated protein kinase-dependent mechanism of melanoma cell death controlled by p53 and reactive oxygen species.},
  author={Monique Elise Verhaegen and Joshua A Bauer and Cristina Mart{\'i}n de la Vega and Gu{\'o}p{\'i}ng W{\'a}ng and Keith G. Wolter and John Chadwick Brenner and Z. Nikolovska-Coleska and Audrey Bengtson and Rajan P. Nair and James T. Elder and Matt Van Brocklin and Thomas E. Carey and Carol R. Bradford and Shaomeng Wang and Mar{\'i}a S Soengas},
  journal={Cancer research},
  year={2006},
  volume={66 23},
  pages={11348-59}
}
The RAS/BRAF/MEK/ERK mitogen-activated protein kinase (MAPK) pathway is emerging as a key modulator of melanoma initiation and progression. However, a variety of clinical studies indicate that inhibiting the MAPK pathway is insufficient per se to effectively kill melanoma cells. Here, we report on a genetic and pharmacologic approach to identify survival factors responsible for the resistance of melanoma cells to MEK/ERK antagonists. In addition, we describe a new tumor cell-selective means to… CONTINUE READING

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