A novel Arabidopsis gene causes Bax-like lethality in Saccharomyces cerevisiae.

@article{KawaiYamada2005ANA,
  title={A novel Arabidopsis gene causes Bax-like lethality in Saccharomyces cerevisiae.},
  author={Maki Kawai-Yamada and Yusuke Saito and Lihua Jin and Taro Ogawa and Kyung-min Kim and Li-hua Yu and Yoshiko Tone and Aiko Hirata and Masaaki Umeda and Hirofumi Uchimiya},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 47},
  pages={39468-73}
}
Overexpression of the mammalian proapoptotic protein Bax induces cell death in plant and yeast cells. The Bax inihibitor-1 (BI-1) gene rescues yeast and plant from Bax-mediated lethality. Using the Arabidopsis BI-1 (AtBI-1) gene controlled by the GAL1 promoter as a cell death suppressor in yeast, Cdf1 (cell growth defect factor-1) was isolated from Arabidopsis cDNA library. Overexpression of Cdf1 caused cell death in yeast, whereas such an effect was suppressed by co-expression of AtBI-1. The… CONTINUE READING
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