A novel ATP-binding cassette transporter from Leishmania is involved in transport of phosphatidylcholine analogues and resistance to alkyl-phospholipids.

@article{CastanysMuoz2007ANA,
  title={A novel ATP-binding cassette transporter from Leishmania is involved in transport of phosphatidylcholine analogues and resistance to alkyl-phospholipids.},
  author={Esther Castanys-Mu{\~n}oz and Nele Alder-Baerens and Thomas Pomorski and Francisco Gamarro and Santiago Castanys},
  journal={Molecular microbiology},
  year={2007},
  volume={64 5},
  pages={1141-53}
}
ATP-binding cassette (ABC) transporters represent an important family of membrane proteins involved in drug resistance and other biological activities. The present work reports the characterization of the first ABC subfamily G (ABCG)-like transporter, LiABCG4, in the protozoan parasite Leishmania. LiABCG4 localized mainly to the parasite plasma membrane. Overexpression of this half-transporter reduced the accumulation of phosphatidylcholine analogues and conferred resistance to alkyl… CONTINUE READING

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