A novel ABCG-like transporter of Trypanosoma cruzi is involved in natural resistance to benznidazole

@inproceedings{Zingales2015ANA,
  title={A novel ABCG-like transporter of Trypanosoma cruzi is
involved in natural resistance to benznidazole},
  author={Bianca Silvana Zingales and Rafael Gomes Aquino Araujo and M. E Villegas Moreno and Jaques Franco and Pedro Henrique Nascimento Aguiar and Solange Lessa Nunes and Marcelo Nunes da Silva and Susan Ienne and Carlos Renato Machado and Adeilton Brand{\~a}o},
  booktitle={Memorias do Instituto Oswaldo Cruz},
  year={2015}
}
Benznidazole (BZ) is one of the two drugs used for Chagas disease treatment. Nevertheless therapeutic failures of BZ have been reported, which were mostly attributed to variable drug susceptibility among Trypanosoma cruzi strains. ATP-binding cassette (ABC) transporters are involved in a variety of translocation processes and some members have been implicated in drug resistance. Here we report the characterisation of the first T. cruzi ABCG transporter gene, named TcABCG1, which is over… CONTINUE READING
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