A novel 5-HT(2A) receptor antagonist exhibits antidepressant-like effects in a battery of rodent behavioural assays: approaching early-onset antidepressants.

@article{Pandey2010AN5,
  title={A novel 5-HT(2A) receptor antagonist exhibits antidepressant-like effects in a battery of rodent behavioural assays: approaching early-onset antidepressants.},
  author={Dilip Kumar Pandey and Radhakrishnan Mahesh and Akutota Ashok Kumar and Vajja Sambasiva Rao and Muralidharan Arjun and Ramamoorthy Rajkumar},
  journal={Pharmacology, biochemistry, and behavior},
  year={2010},
  volume={94 3},
  pages={363-73}
}
Collective evidence suggests that inhibition of neuronal 5-hydroxytryptamine type 2A (5-HT(2A)) receptors contributes to the assuagement of depression-like behaviour in rodents. The present study evaluated the antidepressant-like effect of the 5-((4-benzo [alpha] isothiazol-3-yl) piperazin-1-yl) methyl)-6-chloroindolin-2-one (BIP-1), a compound having affinity to 5-HT(2A) receptors, using a rodent behavioural test battery. Acute BIP-1 (0.25-4mg/kg) pretreatment reduced the quipazine-induced… CONTINUE READING

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