A novel 4E-interacting protein in Leishmania is involved in stage-specific translation pathways

@inproceedings{Zinoviev2011AN4,
  title={A novel 4E-interacting protein in Leishmania is involved in stage-specific translation pathways},
  author={Alexandra Zinoviev and M{\'e}lissa L{\'e}ger and Gerhard Wagner and Michal Shapira},
  booktitle={Nucleic acids research},
  year={2011}
}
In eukaryotes, exposure to stress conditions causes a shift from cap-dependent to cap-independent translation. In trypanosomatids, environmental switches are the driving force of a developmental program of gene expression, but it is yet unclear how their translation machinery copes with their constantly changing environment. Trypanosomatids have a unique cap structure (cap-4) and encode four highly diverged paralogs of the cap-binding protein, eIF4E; none were found to genetically complement a… CONTINUE READING

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