A novel 3D in vitro culture model to study stromal-epithelial interactions in the mammary gland.

@article{Krause2008AN3,
  title={A novel 3D in vitro culture model to study stromal-epithelial interactions in the mammary gland.},
  author={Silva Krause and Maricel V Maffini and Ana M. Soto and Carlos Sonnenschein},
  journal={Tissue engineering. Part C, Methods},
  year={2008},
  volume={14 3},
  pages={261-71}
}
Stromal-epithelial interactions mediate mammary gland development and the formation and progression of breast cancer. To study these interactions in vitro, the development of defined three-dimensional (3D) models is essential. In the present study, we have successfully developed novel 3D in vitro models that allow the formation of mammary gland structures closely resembling those found in vivo. Cocultures of a human mammary epithelial cell line MCF10A and human mammary fibroblasts obtained from… CONTINUE READING
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