A novel 2-stage approach that detects complement activation in patients with antiphospholipid antibody syndrome.

@article{Rand2017AN2,
  title={A novel 2-stage approach that detects complement activation in patients with antiphospholipid antibody syndrome.},
  author={Jacob H. Rand and X Wu and Lucia R Wolgast and Victor Lei and Edward M Conway},
  journal={Thrombosis research},
  year={2017},
  volume={156},
  pages={119-125}
}
INTRODUCTION The antiphospholipid syndrome (APS) is marked by autoantibodies that recognize anionic phospholipids in a cofactor-dependent manner. A role for complement has been implicated in the pathophysiology, however, elevations of complement activation markers have not been consistently demonstrated in clinical studies. We therefore designed a proof-of-principle study to determine whether complement activation might be detectable in APS by first exposing plasmas to phospholipid vesicles… CONTINUE READING