A novel 19q13 nucleolar zinc finger protein suppresses tumor cell growth through inhibiting ribosome biogenesis and inducing apoptosis but is frequently silenced in multiple carcinomas.

@article{Cheng2012AN1,
  title={A novel 19q13 nucleolar zinc finger protein suppresses tumor cell growth through inhibiting ribosome biogenesis and inducing apoptosis but is frequently silenced in multiple carcinomas.},
  author={Yingduan Cheng and Pei Liang and Hua Geng and Zhigang Wang and Lili L. Li and Suk Hang Cheng and Jianming Ying and Xianwei Su and Ka Man Ng and Margaret Ng and Tony S-K Mok and Anthony Tak Cheung Chan and Qian Tao},
  journal={Molecular cancer research : MCR},
  year={2012},
  volume={10 7},
  pages={925-36}
}
Epigenetic disruption of tumor suppressor genes is frequently involved in tumorigenesis. We identified a novel 19q13 KRAB domain-containing zinc finger protein, ZNF545/ZFP82, broadly expressed in normal tissues but downregulated in multiple tumor cell lines. The ZNF545 promoter contains a CpG island, which is frequently methylated in cell lines. The transcriptional silencing of ZNF545 could be reversed by pharmacologic or genetic demethylation, indicating direct epigenetic silencing. ZNF545 was… CONTINUE READING

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