A novel β1 integrin isoform produced by alternative splicing: unique expression in cardiac and skeletal muscle
@article{Flier1995AN, title={A novel β1 integrin isoform produced by alternative splicing: unique expression in cardiac and skeletal muscle}, author={A. van der Flier and I. Kuikman and C. Baudoin and R. van der Neut and A. Sonnenberg}, journal={FEBS Letters}, year={1995}, volume={369} }
The mRNA's of several integrin subunits are alternatively spliced in the region encoding cytoplasmic domains, that may potentially provide alternative integrin‐cytoskeleton interactions and transmembrane signaling pathways. We identified a novel cytoplasmic tail variant of the human β1 subunit by reverse transcriptase polymerase chain reaction. This fourth β1 variant, named β1D, is specific for skeletal and cardica muscle. The determined genomic organization of the 3′‐region of the human β1… CONTINUE READING
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References
SHOWING 1-10 OF 41 REFERENCES
Alternative extracellular and cytoplasmic domains of the integrin alpha 7 subunit are differentially expressed during development.
- Medicine, Biology
- The Journal of biological chemistry
- 1993
- 149
Expression and functional analysis of a cytoplasmic domain variant of the beta 1 integrin subunit
- Biology, Medicine
- The Journal of cell biology
- 1993
- 99
- PDF
Expression of alpha 7 integrin cytoplasmic domains during skeletal muscle development: alternate forms, conformational change, and homologies with serine/threonine kinases and tyrosine phosphatases.
- Biology, Medicine
- Journal of cell science
- 1993
- 166
- PDF
A human integrin beta 1 subunit with a unique cytoplasmic domain generated by alternative mRNA processing.
- Biology, Medicine
- Gene
- 1990
- 118
An alternative form of the integrin beta 1 subunit with a variant cytoplasmic domain.
- Biology, Medicine
- The Journal of biological chemistry
- 1992
- 127
Regulation of Integrin Affinity States through an NP XY Motif in the β Subunit Cytoplasmic Domain (*)
- Biology, Medicine
- The Journal of Biological Chemistry
- 1995
- 185
- PDF
A new isoform of the laminin receptor integrin alpha 7 beta 1 is developmentally regulated in skeletal muscle.
- Biology, Medicine
- The Journal of biological chemistry
- 1993
- 146
Expression of beta 1B integrin isoform in CHO cells results in a dominant negative effect on cell adhesion and motility
- Biology, Medicine
- The Journal of cell biology
- 1994
- 88
- PDF
Occupation of the extracellular matrix receptor, integrin, is a control point for myogenic differentiation
- Biology, Medicine
- Cell
- 1987
- 384
Mapping in vivo associations of cytoplasmic proteins with integrin beta 1 cytoplasmic domain mutants.
- Biology, Medicine
- Molecular biology of the cell
- 1995
- 145