A novel, broad-spectrum inhibitor of enterovirus replication that targets host cell factor phosphatidylinositol 4-kinase IIIβ.

@article{Schaar2013ANB,
  title={A novel, broad-spectrum inhibitor of enterovirus replication that targets host cell factor phosphatidylinositol 4-kinase IIIβ.},
  author={Hilde M. van der Schaar and Pieter Leyssen and Hendrik Jan Thibaut and Armando de Palma and Lonneke van der Linden and Kjerstin H. W. Lanke and C{\'e}line Lacroix and Erik K. Verbeken and Katja Conrath and Angus M Macleod and Dale R Mitchell and Nicholas James Palmer and Herv{\'e} van de Po{\"e}l and Martin J I Andrews and Johan Neyts and Frank J M van Kuppeveld},
  journal={Antimicrobial agents and chemotherapy},
  year={2013},
  volume={57 10},
  pages={4971-81}
}
Despite their high clinical and socioeconomic impacts, there is currently no approved antiviral therapy for the prophylaxis or treatment of enterovirus infections. Here we report on a novel inhibitor of enterovirus replication, compound 1, 2-fluoro-4-(2-methyl-8-(3-(methylsulfonyl)benzylamino)imidazo[1,2-a]pyrazin-3-yl)phenol. This compound exhibited a broad spectrum of antiviral activity, as it inhibited all tested species of enteroviruses and rhinoviruses, with 50% effective concentrations… CONTINUE READING

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References

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Showing 1-10 of 60 references

Enteroviruses as agents of emerging infectious diseases

Journal of NeuroVirology • 2005
View 8 Excerpts
Highly Influenced

Mutations in the nonstructural protein 3A confer resistance to the novel enterovirus replication inhibitor TTP-8307

AM De Palma, HJ Thibaut, +9 authors J. Neyts
Antimicrob. Agents Chemother • 2009
View 10 Excerpts
Highly Influenced

4980 aac.asm.org Antimicrobial Agents and Chemotherapy on Jne 27, 2017 by gest httpaac.asm .rg/ D ow nladed fom

C Spickler, J Lippens, +10 authors Schaar van der
Antimicrob. Agents Chemother • 2013
View 1 Excerpt

Profile of alisporivir and its potential in the treatment of hepatitis

PA Gallay, K. Lin
C. Drug Des. Dev. Ther • 2013

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