A note on testing areas under the curve when using destructive measurement techniques

@article{Heinzl1996ANO,
  title={A note on testing areas under the curve when using destructive measurement techniques},
  author={Harald Heinzl},
  journal={Journal of Pharmacokinetics and Biopharmaceutics},
  year={1996},
  volume={24},
  pages={651-655}
}
The area under the curve of drug concentration over time is considered important in many toxicological, pharmacological, and medical investigations. In case that only one measurement for each experimental unit has been recorded, the area under the curve has to be estimated on the basis of the mean concentration values at the measurement times. Defining an estimator by using a linear combination of these mean values enables the straightforward estimation of the corresponding variance. For… CONTINUE READING

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