A note on single- and two-dose immunogenicity tests of inactive virus vaccine in chicks.

Abstract

Single dose extinction limit test ot inactive polio vaccine in chicks lasts 4 days and offers the same results as the two-dose test which requires 14 days. When "long-term" incubation instead of "conventional" 2 hours-incubation of the serum/virus mixtures in the neutralization reaction was used, extinction limit values higher by 0.6-0.7 log10 were regularly obtained.

Cite this paper

@article{Slonim1976ANO, title={A note on single- and two-dose immunogenicity tests of inactive virus vaccine in chicks.}, author={Donna Slonim and Markus Drevo}, journal={Journal of hygiene, epidemiology, microbiology, and immunology}, year={1976}, volume={21 3}, pages={368-70} }