A note on power approximations for the transmission/disequilibrium test.

  title={A note on power approximations for the transmission/disequilibrium test.},
  author={Michael Knapp},
  journal={American journal of human genetics},
  volume={64 4},
  • Michael Knapp
  • Published 1999 in American journal of human genetics
The transmission/disequilibrium test (TDT) is a popular method for detection of the genetic basis of a disease. Investigators planning such studies require computation of sample size and power, allowing for a general genetic model. Here, a rigorous method is presented for obtaining the power approximations of the TDT for samples consisting of families with either a single affected child or affected sib pairs. Power calculations based on simulation show that these approximations are quite… CONTINUE READING

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