A note on power approximations for the transmission/disequilibrium test.

@article{Knapp1999ANO,
  title={A note on power approximations for the transmission/disequilibrium test.},
  author={Michael Knapp},
  journal={American journal of human genetics},
  year={1999},
  volume={64 4},
  pages={1177-85}
}
  • Michael Knapp
  • Published 1999 in American journal of human genetics
The transmission/disequilibrium test (TDT) is a popular method for detection of the genetic basis of a disease. Investigators planning such studies require computation of sample size and power, allowing for a general genetic model. Here, a rigorous method is presented for obtaining the power approximations of the TDT for samples consisting of families with either a single affected child or affected sib pairs. Power calculations based on simulation show that these approximations are quite… CONTINUE READING

From This Paper

Figures and tables from this paper.
59 Citations
10 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 59 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 10 references

Association studies in genetic ep

  • MP Baur, M Knapp
  • 1997
1 Excerpt

Distributions in statistics: continuous multivariate distributions

  • NL Johnson, S Kotz
  • 1972
1 Excerpt

Linear statistical inference and its applications. 2d ed

  • CR Rao
  • 1972

Similar Papers

Loading similar papers…