A note on non-parametric ANCOVA for covariate adjustment in randomized clinical trials.

@article{Lesaffre2003ANO,
  title={A note on non-parametric ANCOVA for covariate adjustment in randomized clinical trials.},
  author={Emmanuel Lesaffre and Stephen Senn},
  journal={Statistics in medicine},
  year={2003},
  volume={22 23},
  pages={3583-96}
}
Koch et al. recently (1998) proposed two covariate-adjusted approaches for the comparison of continuous, ordinal and binary responses in a randomized clinical trial (Statist. Med. 1998; 17: 1863-1892). The first is a randomization approach while the second assumes that the study is a sample of a population. Here, we study the second approach and consider the simplest cases of two treatments with a continuous response and with a binary response. Koch's second approach will be compared with the… CONTINUE READING