A note on inference of trait associations with SNP haplotypes and other attributes in generalized linear models.

@article{Burkett2004ANO,
  title={A note on inference of trait associations with SNP haplotypes and other attributes in generalized linear models.},
  author={Kelly M. Burkett and Brad McNeney and Jinko Graham},
  journal={Human heredity},
  year={2004},
  volume={57 4},
  pages={200-6}
}
Recently, Lake et al. [Human Heredity 2003;55:56-65] have proposed an approach based on the EM algorithm for maximum-likelihood inference of trait associations with haplotypes and environmental cofactors in generalized linear models. In this short report, we describe an extension to accommodate missing SNP genotype information. We also discuss differences in the calculation of standard errors between their implementation and our own. Finally, we present results indicating that inference is… CONTINUE READING