A norbergenin derivative inhibits neuronal cell damage induced by tunicamycin.

@article{Suzuki2006AND,
  title={A norbergenin derivative inhibits neuronal cell damage induced by tunicamycin.},
  author={Shinya Suzuki and Yui Okuse and Masafumi Kawase and Masufumi Takiguchi and Yoshiyasu Fukuyama and Hironobu Takahashi and Masao Sato},
  journal={Biological & pharmaceutical bulletin},
  year={2006},
  volume={29 7},
  pages={
          1335-8
        }
}
Several chemically synthesized compounds were examined for protective effects against the cell damage in tunicamycin-treated human neuroblastoma IMR-32 cells. Among the compounds tested, an antioxidant, Norbergenin-11-caproate (10 microM), exhibited complete protection against the cell growth inhibitory effect of tunicamycin but did not inhibit the induction of Bip/GRP78 mRNA by tunicamycin. Both norbergenin-11-caproate and alpha-tocopherol completely inhibited the production of reactive oxygen… CONTINUE READING

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