A noradrenergic lesion exacerbates neurodegeneration in a Down syndrome mouse model.

@article{Lockrow2011ANL,
  title={A noradrenergic lesion exacerbates neurodegeneration in a Down syndrome mouse model.},
  author={Jason P. Lockrow and Heather A Boger and Greg Gerhardt and Gary Aston-Jones and David Alan Bachman and A. -Ch. Granholm},
  journal={Journal of Alzheimer's disease : JAD},
  year={2011},
  volume={23 3},
  pages={
          471-89
        }
}
Individuals with Down syndrome (DS) acquire Alzheimer's-like dementia (AD) and associated neuropathology earlier and at significantly greater rates than age-matched normosomic individuals. However, biological mechanisms have not been discovered and there is currently limited therapy for either DS- or AD-related dementia. Segmental trisomy 16 (Ts65Dn) mice provide a useful model for many of the degenerative changes which occur with age in DS including cognitive deficits, neuroinflammation, and… CONTINUE READING
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